In vitro screening of the library enables identification of functionally active Pept-ins, which we subsequently characterize, optimize and test in vivo
Our algorithm determines the most promising APR sequences are chosen for Pept-in design
Based on physiological insights in the biology of the disease, the Pept-in™ protein target(s) is selected and its protein sequence identified.
Based on this sequence, the ‘TANGO’ algorithm identifies all APRs within the target protein and assigns a score. Subsequently the most promising APR sequences are selected for Pept-in™ design.
The library is screened in vitro to identify functionally active Pept-ins™, which are then characterized, optimized and further screened in vivo