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Target selection

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Based on physiological insights in the biology of the disease, the Pept-in protein target(s) is selected and its protein sequence identified.

APR identification

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Based on this sequence, the  ‘TANGO’ algorithm identifies all APRs within the target protein and assigns a score. Subsequently the most promising APR sequences are selected for Pept-in™ design.

Functional testing

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The library is screened in vitro to identify functionally active Pept-ins™, which are then characterized, optimized and further screened in vivo