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Aelin Therapeutics will be presenting live at Bio€quity Europe.

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Proud to be selected as ‘Presenting Company Class of 2022’ with live presentation during the ‘Hot Topics Track’ at the 22nd Bio€quity Europe Conference, hosted by BioCentury and EBD (May 16th -…

Aelin Therapeutics will be speaking at the Undruggable leaders forum Europe.

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Please join Els Beirnaert, CEO, presenting on April 13th and 14th 2021
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Aelin Therapeutics awarded €2.3 million VLAIO research grant

| Press Releases, General news | No Comments
Funding will enable accelerated development of unique Pept™-in-based cancer therapeuticsLeuven, BELGIUM – 9 July 2020 – Aelin Therapeutics NV, an emerging biotechnology company focused on the discovery and development of…
Prediction of sequence-dependent and mutational effects on the aggregation of peptides and proteins

Prediction of sequence-dependent and mutational effects on the aggregation of peptides and proteins

| Scientific publications | No Comments
We have developed a statistical mechanics algorithm, TANGO, to predict protein aggregation. TANGO is based on the physico-chemical principles of b-sheet formation, extended by the assumption that the core regions…
Nature Communications 2020 Michiels

Reverse engineering synthetic antiviral amyloids

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Human amyloids have been shown to interact with viruses and interfere with viral replication. Based on this observation, we employed a synthetic biology approach in which we engineered virus-specific amyloids…

Aggregating sequences that occur in many proteins constitute weak spots of bacterial proteostasis

| Anti bacterials, Scientific publications | No Comments
Aggregation is a sequence-specific process, nucleated by short aggregation-prone regions (APRs) that can be exploited to induce aggregation of proteins containing the same APR. Here, we find that most APRs…

De novo design of a biologically active amyloid

| High value, undruggable targets, Scientific publications | No Comments
Amyloid aggregation is driven by short sequences within proteins that self-assemble into characteristic amyloid structures. About 30 human proteins are implicated in amyloid-associated diseases, but many more contain short sequences…