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Prediction of sequence-dependent and mutational effects on the aggregation of peptides and proteins

Prediction of sequence-dependent and mutational effects on the aggregation of peptides and proteins

| Scientific publications | No Comments
We have developed a statistical mechanics algorithm, TANGO, to predict protein aggregation. TANGO is based on the physico-chemical principles of b-sheet formation, extended by the assumption that the core regions…
Nature Communications 2020 Michiels

Reverse engineering synthetic antiviral amyloids

| Scientific publications | No Comments
Human amyloids have been shown to interact with viruses and interfere with viral replication. Based on this observation, we employed a synthetic biology approach in which we engineered virus-specific amyloids…

Aggregating sequences that occur in many proteins constitute weak spots of bacterial proteostasis

| Anti bacterials, Scientific publications | No Comments
Aggregation is a sequence-specific process, nucleated by short aggregation-prone regions (APRs) that can be exploited to induce aggregation of proteins containing the same APR. Here, we find that most APRs…

De novo design of a biologically active amyloid

| High value, undruggable targets, Scientific publications | No Comments
Amyloid aggregation is driven by short sequences within proteins that self-assemble into characteristic amyloid structures. About 30 human proteins are implicated in amyloid-associated diseases, but many more contain short sequences…